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About Rome, GA

People of the Mississippian culture are known to have inhabited the area from about 1000 CE. These people are believed to have died off from disease brought by exposure to the Spaniards in the late 16th century. The Cherokee migrated into the Southeast and established themselves in the early 17th century. Specifics before the Spanish expeditions in the 16th century are largely unknown, but archeologists have found evidence of thousands of years of indigenous cultures along these rivers. There is some debate over whether Hernando de Soto was the first Spanish conquistador to encounter Native Americans in the area now known as Rome, but it is usually agreed that he passed through the region with his expedition in 1540.